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Review Article 2026CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Targeting pancreatic cancer with natural compounds: molecular mechanisms, preclinical evidence, clinical perspectives, and limitations

Alberto Orta, Miguel Angel Hidalgo-Leon, Carlos Lacalle-Gonzalez, Miriam M. Rodriguez de Lope, Lara Sanz-Criado, Jesus Garcia-Foncillas +1 more

Pancreatic cancer remains one of the most aggressive and lethal malignancies, with poor survival outcomes and limited therapeutic options. Surgical resection is currently the only potentially curative treatment; however, fewer than 20% of patients are eligible for this at diagnosis due to the stage of the advanced disease. Despite substantial progress in understanding the molecular pathogenesis of pancreatic cance…

Frontiers in Pharmacology PubMed Central Open Access↗

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