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Research Article 2026CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

α1-Antitrypsin attenuates microglial NLR family pyrin domain containing 3 inflammasome activation via cannabinoid receptor 2 signaling to ameliorate α-synucleinopathy-related behavioral deficits.

Linjuan Feng, Hsuan Lo, Weipin Weng, Jiahao Zheng, Yixin Sun, Wei Lin +3 more

α-Synucleinopathies are marked by persistent neuroinflammation and disabling non-motor symptoms involving nucleus accumbens (NAc) dysfunction, yet the neuroimmune mechanisms linking microglial activation to accumbal synaptic pathology remain poorly understood. Here, we identify α1-antitrypsin (AAT) as a previously unrecognized modulator of cannabinoid receptor 2 (CB2R)-associated signaling in α-syn pathology. An a…

α1-Antitrypsin (AAT)Cannabinoid receptor 2 (CB2R)α-Synucleinopathies Microglial NLRP3 inflammasome Nucleus accumbens (NAc)Dopamine receptor type 2-expressing medium spiny neurons (D2-MSNs)

Molecular Biomedicine PubMed Central Open Access↗

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