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Research Article 2026CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Ontogeny of Endocannabinoid Modulation of Neuromuscular Transmission: Contribution of Postsynaptic Nicotinic Receptors and Butyrylcholinesterase-Sensitive Mechanisms

Egor Nevsky, Oksana Lenina, Irina Zueva, Dmitry Samigullin, Artem Malomouzh, Vladimir Parpura +1 more

Highlights What are the main findings? CB1 receptors modulate acetylcholine release only in developing synapses and require postsynaptic nicotinic receptors.Butyrylcholinesterase degrades endocannabinoids to tune this signaling. What are the implications of the main findings? This presynaptic–postsynaptic coupling reveals a novel retrograde homeostatic mechanism essential for synapse maturation.Non-canonical endoc…

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