Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
63 articles
Newest firstBackground and aims On 9 June 2022, Thailand changed its cannabis legislation, expanding access to individuals aged >18 years. Evidence suggests that such changes could increase the risk of cannabis use and related harms, and could influence patterns of use of other substances among adolescents. This study measured the potential impact of these legislative changes on adolescent substance-related hospital admission…
Open article record in new tab ↗Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions. Design Case-control, observational postmortem study comparing gene expression in brain tissue fr…
Background Over two decades of pharmacotherapy research has yet to yield a consistently effective medication for cannabis use disorder (CUD), in part because clinical trials have frequently prioritized abstinence as a primary or key endpoint. Abstinence, however, is difficult for many patients to attain, may not align with their treatment goals, and can obscure meaningful clinical improvements. By contrast, the al…
Open article record in new tab ↗Aims To estimate the prevalence of prenatal cannabis use in Michigan, USA, using self-reports and urine toxicology and to examine factors associated with use. Design Observational study using data from the Michigan Archive for Research on Child Health (MARCH) cohort, part of the National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) program. It is a prospective statewide pregnancy…
Aims To test whether the total consumption model and its extension, the theory of collectivity, apply to adolescent cannabis use. We estimated: (1) whether the distribution of cannabis use frequency was stable over time; (2) whether changes in average cannabis use were mirrored across consumption quantiles; and (3) whether higher average use corresponds with a higher prevalence of high-frequency users. Design Repe…
Open article record in new tab ↗Background and aims NEET (Not in Employment, Education or Training) youth represent a vulnerable population from a public health perspective, facing multiple health challenges, including elevated substance use. Tobacco and cannabis are the most commonly used psychoactive substances among young people, with early initiation associated with long-term health and social consequences. While evidence suggests associatio…
Open article record in new tab ↗Background and aims Cannabis cue reactivity paradigms are instrumental in studying the behavioral and neurocognitive mechanisms of cannabis use and cannabis use disorders; however, image sets used for cannabis cue reactivity paradigms vary between studies, and the lack of reliability and validity assessment hinders the quality of evidence they generate. The main aim of this study was to create a novel, open access…
Background and aims Epidemiologic research suggests that adolescent cannabis use is associated with psychological distress (i.e. depression and anxiety symptoms); however, most studies have relied on 20th-century data, when cannabis was significantly less potent than today. This study aimed to estimate the association between adolescent cannabis use and psychological distress using contemporary population-based da…
Background and aims Data on the presence of new psychoactive substances (NPS) mainly originate from drug-checking, law enforcement and wastewater analysis sources, while data on NPS poisonings are scarce. In Europe, the documented incidence rate of NPS poisonings is highest in the Netherlands. We investigated temporal trends in NPS poisonings reported to the Dutch Poisons Information Center (DPIC) between 2012 and…
Background and aims Sexual minority youth report significantly higher rates of substance use than heterosexual youth, yet a comprehensive and systematic evaluation and synthesis of the magnitude of this inequity has not been conducted. The purpose of this study was to conduct a meta-analysis to assess the magnitude of overall inequities in substance use between sexual minority and heterosexual youth and examine de…
Open article record in new tab ↗Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity. This study aimed to develop a practical risk score for SCRAs prevalent in Germany between 2013 and 2021, based on prevalence data and differentiated data on intox…
Background and aims The impact of exposure to cannabis dispensaries on young adult cannabis use may depend on how exposures and outcomes are defined. We estimated associations of dispensary exposure with young adult cannabis use across: (a) a government-maintained licensed dispensaries registry versus a web-scraped list of licensed and unlicensed dispensaries; and (b) varying modes of cannabis modes (i.e. smoked,…
Background and aims The global cannabidiol (CBD) market has expanded in recent years. Several studies suggest CBD use, whether for medical or recreational purposes, is on the rise; however, no systematic assessments of its prevalence have been conducted so far. This meta-analysis aimed to estimate the prevalence of CBD use in North America and Europe independently. Methods Searches were conducted in PubMed, PsycIN…
Open article record in new tab ↗Aims To identify variation in identification of medical consumers using alternative self-reported measures and assess whether differences in these rates exist across jurisdictions with different medical policy approaches using evidence from an international study on cannabis use. Design Secondary analysis of wave 4 (2021) of the International Cannabis Policy Study (ICPS) cross-sectional survey. Setting United Stat…
Background and aims Ecological momentary assessment (EMA) studies have previously demonstrated a prospective influence of craving on substance use in the following hours. Conceptualizing substance use as a dynamic system of causal elements could provide valuable insights into the interaction of craving with other symptoms in the process of relapse. The aim of this study was to improve the understanding of these da…
Aims To measure the associations between racial discrimination and distinct alcohol and other drug use outcomes in minoritised racial/ethnic groups and to explore the moderating roles of demographic and methodological characteristics. Methods Quantitative studies including racial discrimination as an exposure (both binary and continuous), an alcohol and/or other drug use outcome and a minoritised racial/ethnic sam…
Pre-clinical research and case reports have linked cannabis use to myocardial infarction (MI) since the 1970s. The association with MI may be specific to certain types and patterns of cannabis use as well as certain consumer characteristics; however, due to limited data availability, meta-analyses examining the association between cannabis use and MI typically report only broad binary categorisations of use vs. no…
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