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Author: Markus Werner

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Research Article 2026CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Tocotrienol metabolites redirect lipid mediator production in innate immune cells towards inflammation resolution.

Stephan Permann, Elena Brunner, Khaled Alsabil, Markus Werner, Lorenz Waltl, Guillaume Viault +15 more

Restoring homeostasis in persistent inflammation requires suppressing the inflammatory response and promoting resolution. Currently, no clinically used small molecules intentionally achieve both effects. Endogenous long-chain vitamin E metabolites (LCMs) address inflammation at multiple sites, including pro-inflammatory leukotriene production and cytokine release, thus limiting inflammation. Among LCMs, we here id…

Acta Pharmaceutica Sinica. B PubMed Central Open Access↗

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