Nabilone
Nabilone capsules (4 mg)
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Despite the prevalence of cannabis use among the PTSD population and self-reports that it is used to help cope with PTSD symptoms, the direct effects of cannabis on PTSD symptomology are unknown. The purpose of this placebo-controlled, within-subject study is to assess the effects of smoked cannabis and orally administered nabilone, a synthetic analog of THC, the primary psychoactive component of cannabis on multiple dimensions of PTSD symptomatology in cannabis smokers with PTSD.
Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2022-07-15
What this record can show
Results are reported by the registry submitter and preserved exactly. They are not independent verification or a treatment recommendation.
Registry facts
This study will compare the effects of smoked cannabis and nabilone on attentional bias toward trauma- related stimuli, subjective and emotional processing to a range of trauma-and non-trauma-related images and physiological reactivity to these stimuli in individuals with CUD and PTSD. Importantly, this study will also probe the abuse related potential of nabilone compared to smoked cannabis in this population, a critical aspect in determining the potential feasibility for its use clinically to treat CUD in PTSD populations. The effects of nabilone will be compared to propranolol as a positive control.
Linked local records
Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.
Interventions
Nabilone capsules (4 mg)
Cigarettes (0.0 and 5.6% THC)
Propranolol capsules (40mg)
Placebo capsules
Source-reported results
Results are reported by the registry submitter and preserved exactly. They are not independent verification or a treatment recommendation.
We cannot provide data as the study was terminated due to lack of feasibility. The staff responsible for data collection, organization, and cleaning have left the institution; we have made every effort to locate the data for the two participants who completed the study, but have been unsuccessful. We do not have access to the data.
Population: We cannot provide data as the study was terminated due to lack of feasibility. The staff responsible for data collection, organization, and cleaning have left the institution; we have made every effort to locate the data for the two participants who completed the study, but have been unsuccessful. We do not have access to the data.
The study was terminated and the PI and the study team left the institution; as such, no outcome data is available.
| Milestone | Active Nab > Plac Prop > Plac Cann | Plac Nab > Act Prop > Plac Cann | Plac Nab > Plac Prop > Act Cann | Plac Nab > Plac Prop > Plac Cann |
|---|---|---|---|---|
| STARTED | 1 | 1 | 1 | 1 |
| COMPLETED | 1 | 1 | 0 | 0 |
| NOT COMPLETED | 0 | 0 | 1 | 1 |
Eligibility
primary outcomes
Time frame: 1 month
We cannot provide data as the study was terminated due to lack of feasibility. The staff responsible for data collection, organization, and cleaning have left the institution; we have made every effort to locate the data for the two participants who completed the study, but have been unsuccessful. We do not have access to the data.
Publications
No exact PMID-linked public article is currently readable locally.