INTERVENTIONALCOMPLETEDNCT00838448

Interactions Between Physical Activity and Cannabis Use in Adults

In this study the investigators will explore the relationship between physical activity and cannabis use. The investigators will compare regional brain activation detected by imaging technique(fRMI) before and after exercise in cannabis users and compare results with results from controls. The investigators hypothesize that the regional brain activation in response to visual cues (pictures related to cannabis use and food) will be different in cannabis users than in controls and that exercise will significantly alter brain responses to the cues.

Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2013-06-12

What this record can show

Protocol only - no registry results posted

This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.

Registry facts

Study at a glance

Phase: NA
Enrollment: 30 (ACTUAL)
Start date: 2009-01
Sponsor: Vanderbilt University
Design: NON RANDOMIZED · PARALLEL · DIAGNOSTIC
Locations: 1
Results record: Not present in registry snapshot

It is unknown how the response of cannabis users might compare to those of non-users in response to similar dose of physical activity. We will therefore compare brain activation during craving to cannabis, a natural reward (food) and a neutral scene (nature images). The food cues will allow us to determine if effects of exercise on brain activation and craving generalize to two different reward conditions and the nature scenes provide a neutral, no rewarding control. In addition to the analysis of predetermined regions of interest, whole-brain exploratory analyses will also be conducted to examine for additional brain regions showing associations between various conditions of interest and regional brain activation. Specific Aims 1\. To explore methodological factors involved in finding the relationship between PA and cannabis use. 1. to examine the effects of cannabis and food cues on brain activation and craving in cannabis users and nonusers 2. to examine the effects of vigorous exercise on brain activation and craving in response to cannabis and food cues. Our working hypothesis is that the regional brain activation in response to drug cues will be different in cannabis users than in controls and that exercise will significantly alter brain responses to these cues in both groups. Our secondary hypothesis is that exercise will tend to normalize the abnormal brain activation observed in cannabis users. Our expectation is that exercise will alter cue-responding in terms of brain activation or craving. It is possible that exercise may be a useful treatment in cannabis dependence. Future studies may examine this specific relationship. There are no reports available exploring the relationship between physical activity and cannabis use. Current data suggest that there are convergent findings regarding the chronic and acute effects of cannabis on brain activity

Linked local records

Related local records

Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.

Conditions

No published condition report matched.

Cannabinoids and active compounds

No governed compound link was found.

Medicines

No exact medicine-name link was found.

Research network

Researchers and organizations

Evonne J. Charboneau Maciej Buchowski Mary S. Dietrich Natalie N. Meade Peter Martin Ronald Cowan Sohee Park Cognitive Neuroimaging Lab Vanderbilt Psychiatric Hospital Vanderbilt University

Interventions

What was registered

BEHAVIORAL

Exercise

Exercise performed on a treadmill for 20-30 minutes

Eligibility

Population and criteria

Sex: ALL
Minimum age: 18 Years
Maximum age: 35 Years
Healthy volunteers: Accepted

Inclusion criteria

Cases and Controls must:
Be able to understand the study and provide written informed consent.
Be male or female 18 -35 years of age.
Be in generally good health
If female of childbearing potential, have a negative serum pregnancy test on study day Cases must:
Meet criteria for cannabis dependence as primary diagnosis as determined by the Substance Abuse module of SCID (Structured Clinical Interview for DSM-IV).
Not currently seeking treatment for cannabis dependence.
Have a positive urine drug test for cannabis on the study day
Avoid alcohol and other recreational drug use (except cannabis and/or nicotine) for 48 h before testing.

Exclusion criteria

Cases and Controls must not:
Be pregnant or lactating
Have implanted electrical medical device (e.g. pacemaker, vagal nerve stimulator)
Have non-secure metallic foreign bodies
Have met criteria for another axis 1 diagnosis in the past 6 months
Receive psychotropically active or vasoactive medications (within 6 weeks of screen day)
Have chronic medical illness
Have epilepsy
Have a history of head injury that required hospitalization
Have claustrophobia
Have orthopedic or other problems precluding them from performing exercise protocol
Have body mass index (BMI) less than 19 kg/m2
Weighing more than 275 pounds (MRI table limit) Cases must not:
Have current dependence, as determined by the SCID, on any psychoactive substance other than nicotine and/or cannabinoid
Have any serious medical or psychiatric illnesses and/or clinically significant symptoms, which in the judgment of the PI or his/her designee would make them unsafe, or would make compliance with the study protocol difficult or put the study staff at undue risk

primary outcomes

primary measures

Craving for cannabis

Time frame: 1 hour

Publications

Locally readable linked articles

linked publication

Aerobic Exercise Training Reduces Cannabis Craving and Use in Non-Treatment Seeking Cannabis-Dependent Adults

PLoS ONE · Free full text

Snapshot provenance

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