INTERVENTIONALTERMINATEDNCT00046709

Marijuana in Combination With Opioids for Cancer Pain: A Pilot Study

To find out if it is safe and effective to use smoked marijuana in combination with opioids to treat cancer pain. The study will evaluate whether smoked marijuana, when used with opioids, will have an effect on pain relief, and to see if marijuana reduces the side effects of opioids, which include nausea and/or vomiting.

Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2013-10-10

What this record can show

Protocol only - no registry results posted

This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.

Registry facts

Study at a glance

Phase: PHASE1, PHASE2
Enrollment: 16
Start date: 2002-09
Sponsor: Center for Medicinal Cannabis Research
Design: NON RANDOMIZED · SINGLE GROUP · TREATMENT
Locations: 1
Results record: Not present in registry snapshot

To take part in this study, you must have ongoing cancer pain which is currently being treated with opioids. If you meet all the eligibility criteria you will be admitted to the General Clinical Research Center at San Francisco General Hospital for 9 days. The treatment consists of smoking one marijuana cigarette 3 times a day.

Linked local records

Related local records

Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.

Conditions

Cancer Pain

Cannabinoids and active compounds

No governed compound link was found.

Medicines

No exact medicine-name link was found.

Interventions

What was registered

DRUG

Smoked Marijuana

Eligibility

Population and criteria

Sex: ALL
Minimum age: 18 Years
Maximum age: Not reported
Healthy volunteers: Not accepted

Inclusion criteria

Have ongoing cancer pain
Be diagnosed with cancer and have at least a six month survival.
Be on a stable dose of opioid medication for at least 2 weeks before enrollment.
Have smoked marijuana on at least 6 occasions in their lifetime prior to enrollment.

Exclusion criteria

You must not:
Start chemotherapy, radiation or biphosphonates during the study, or have received any new intervention with any such agents within the past 4 weeks.
Currently be using smoked tobacco products.
Currently be in methadone treatment.
Have smoked marijuana within 30 days of enrollment.
Be diagnosed with diabetes mellitus.
Have severe heart disease, uncontrolled hypertension, or lung disease.
Currently be receiving treatment with corticosteroids.
Be pregnant or breastfeeding.

primary outcomes

primary measures

Change in level of cancer pain as recorded on a 100mm Visual Analog Scale.

secondary outcomes

secondary measures

Change in level of experimentally induced pain on a 100mm Visual Analog Scale.

Change in nausea and emesis in participants exhibiting these symptoms.

Change in disposition kinetics of opioid analgesics.

Publications

Locally readable linked articles

No exact PMID-linked public article is currently readable locally.

Snapshot provenance

Snapshot: dc506655-4a08-4519-a940-dbdc1ec8fcf3
Retrieved: 24/09/2026, 14:14:19
SHA-256: 958c1ac5e1c77c7f512ceb35a75a9639ef0f845a220a06946c72fb228132e8c8