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Author: Dalma Biri

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Research Article 2026CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasis.

Szabolcs Takács, Katalin Skrapits, Balázs Göcz, Éva Rumpler, Miklós Sárvári, Barbara Göblyös +5 more

We present and validate a pioneering 'IHC/LCM-Seq' method for transcriptome profiling of spatially defined neuronal cell types detected with immunohistochemistry in sections of formaldehyde-fixed human brains. Application of IHC/LCM-Seq to male human hypothalami enables the identification of 14,000-16,000 transcripts in agouti-related protein (AgRP) neurons, which drive appetite and energy storage, and proopiomela…

Molecular neuroscience Hypothalamus

Nature Communications PubMed Central Open Access↗

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